Journal article
Empiric Quadruple vs. Triple Therapy for Primary Treatment of Helicobacter pylori Infection: Systematic Review and Meta-Analysis of Efficacy and Tolerability
Abstract
OBJECTIVES: Recent treatment guidelines recommend two first-line therapies for Helicobacter pylori infection: proton pump inhibitor (PPI), bismuth, tetracycline, and metronidazole (quadruple therapy) or PPI, clarithromycin, and amoxicillin (triple therapy). We performed a systematic review and meta-analysis to compare the efficacy and tolerability of these regimens as first-line treatment of H. pylori.
METHODS: A search of MEDLINE, EMBASE, …
Authors
Luther J; Higgins PDR; Schoenfeld PS; Moayyedi P; Vakil N; Chey WD
Journal
The American Journal of Gastroenterology, Vol. 105, No. 1,
Publisher
Wolters Kluwer
Publication Date
1 2010
DOI
10.1038/ajg.2009.508
ISSN
0002-9270
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AmoxicillinAntacidsAnti-Bacterial AgentsAnti-Infective AgentsBismuthClarithromycinDrug Therapy, CombinationHelicobacter InfectionsHelicobacter pyloriHumansMetronidazoleOutcome Assessment, Health CarePatient CompliancePractice Guidelines as TopicProton Pump InhibitorsRandomized Controlled Trials as TopicTetracycline