Journal article
Predictive control of crystal size distribution in protein crystallization
Abstract
This work focuses on the modelling, simulation and control of a batch protein crystallization process that is used to produce the crystals of tetragonal hen egg-white (HEW) lysozyme. First, a model is presented that describes the formation of protein crystals via nucleation and growth. Existing experimental data are used to develop empirical models of the nucleation and growth mechanisms of the tetragonal HEW lysozyme crystal. The developed …
Authors
Shi D; Mhaskar P; El-Farra NH; Christofides PD
Journal
Nanotechnology, Vol. 16, No. 7,
Publisher
IOP Publishing
Publication Date
July 1, 2005
DOI
10.1088/0957-4484/16/7/034
ISSN
0957-4484