Journal article
MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer
Abstract
Lung cancer is the first cause of cancer death worldwide and the Hippo pathway transcriptional coactivators YAP/TAZ have a pro-oncogenic role in this context. In order to understand the mechanisms through which YAP/TAZ elicit their oncogenic role in different systems, many studies are focused on YAP/TAZ target genes involved in the regulation of cell proliferation/survival and migration. However, there is scarce evidence on the role of YAP/TAZ …
Authors
Sardo FL; Forcato M; Sacconi A; Capaci V; Zanconato F; Di Agostino S; Del Sal G; Pandolfi PP; Strano S; Bicciato S
Journal
Carcinogenesis, Vol. 38, No. 1, pp. 64–75
Publisher
Oxford University Press (OUP)
Publication Date
1 2017
DOI
10.1093/carcin/bgw110
ISSN
0143-3334
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcyltransferasesAdaptor Proteins, Signal TransducingCarcinogenesisCarcinoma, Non-Small-Cell LungCell ProliferationGene Expression Regulation, NeoplasticHumansLung NeoplasmsMicroRNAsMinichromosome Maintenance Complex Component 7PhosphoproteinsTranscription FactorsTumor Cells, CulturedYAP-Signaling Proteins