Journal article
Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Abstract
OBJECTIVE: To identify risk alleles relevant to the causal and biologic mechanisms of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
METHODS: A genome-wide association study and subsequent replication study were conducted in a total cohort of 1,986 cases of AAV (patients with granulomatosis with polyangiitis [Wegener's] [GPA] or microscopic polyangiitis [MPA]) and 4,723 healthy controls. Meta-analysis of these data sets …
Authors
Merkel PA; Xie G; Monach PA; Ji X; Ciavatta DJ; Byun J; Pinder BD; Zhao A; Zhang J; Tadesse Y
Journal
Arthritis & Rheumatology, Vol. 69, No. 5, pp. 1054–1066
Publisher
Wiley
Publication Date
May 2017
DOI
10.1002/art.40034
ISSN
2326-5191
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisAutoantigensB-LymphocytesCase-Control StudiesFemaleGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyGranulomatosis with PolyangiitisHLA-DP AntigensHLA-DP beta-ChainsHaplotypesHumansMaleMicroscopic PolyangiitisMiddle AgedMonocytesMyeloblastinNeutrophilsOdds RatioPeroxidasePolymorphism, Single NucleotideProtein Tyrosine Phosphatase, Non-Receptor Type 22T-Lymphocytesalpha 1-Antitrypsin