Journal article
Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact
Abstract
In this work, we hypothesize that a surface modified with both polyethylene glycol (PEG) and hirudin may provide a non-fouling, thrombin-neutralizing surface suitable for blood contacting applications. With gold as a model substrate we used two different approaches to the preparation of such a surface: (1) a "direct" method in which PEG was conjugated to hirudin and the conjugate was then immobilized on the gold; (2) a "sequential" method in …
Authors
Alibeik S; Zhu S; Brash JL
Journal
Colloids and Surfaces B Biointerfaces, Vol. 81, No. 2, pp. 389–396
Publisher
Elsevier
Publication Date
12 2010
DOI
10.1016/j.colsurfb.2010.07.024
ISSN
0927-7765