Journal article
In Vitro Generation of Human High-Density-Lipoprotein-Resistant Trypanosoma brucei brucei
Abstract
The host range of African trypanosomes is influenced by innate protective molecules in the blood of primates. A subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I, apolipoprotein L-I, and haptoglobin-related protein is toxic to Trypanosoma brucei brucei but not the human sleeping sickness parasite Trypanosoma brucei rhodesiense. It is thought that T. b. rhodesiense evolved from a T. b. brucei-like ancestor and …
Authors
Faulkner SD; Oli MW; Kieft R; Cotlin L; Widener J; Shiflett A; Cipriano MJ; Pacocha SE; Birkeland SR; Hajduk SL
Journal
mSphere, Vol. 5, No. 8, pp. 1276–1286
Publisher
American Society for Microbiology
Publication Date
8 2006
DOI
10.1128/ec.00116-06
ISSN
1556-6811