Journal article
Zinc Deficiency Exacerbates Loss in Blood-Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI (44477)
Abstract
Using dynamic Magnetic Resonance Imaging (dMRI), blood-brain barrier (BBB) permeability (k(PSrho)) and tissue interstitial leakage space (v(e)) were evaluated in zinc-deficient (ZnDF) male weanling Wistar rats following 3 days exposure to hyperoxia (85% O2). Temporal monitoring of T1-weighted MR image changes, following a bolus intravenous injection of gadolinium-DTPA, allowed estimation of BBB integrity. Three-day exposure of hyperoxia caused …
Authors
Noseworthy MD; Bray TM
Journal
Experimental Biology and Medicine, Vol. 223, No. 2, pp. 175–182
Publisher
Wiley
Publication Date
2 2000
DOI
10.1177/153537020022300210
ISSN
1535-3702