Journal article
Elevated immunoglobulin levels in the cerebrospinal fluid from lupus-prone mice
Abstract
The systemic autoimmune disease lupus erythematosus (SLE) is frequently accompanied by neuropsychiatric manifestations and brain lesions of unknown etiology. The MRL-lpr mice show behavioral dysfunction concurrent with progression of a lupus-like disease, thus providing a valuable model in understanding the pathogenesis of autoimmunity-induced CNS damage. Profound neurodegeneration in the limbic system of MRL-lpr mice is associated with …
Authors
Sidor MM; Sakic B; Malinowski PM; Ballok DA; Oleschuk CJ; Macri J
Journal
Journal of Neuroimmunology, Vol. 165, No. 1-2, pp. 104–113
Publisher
Elsevier
Publication Date
8 2005
DOI
10.1016/j.jneuroim.2005.04.022
ISSN
0165-5728
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlood-Brain BarrierCerebrospinal Fluid ProteinsElectrophoresis, Gel, Two-DimensionalImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulinsLupus Erythematosus, SystemicMaleMiceMice, Inbred MRL lprNeurodegenerative DiseasesSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization