Journal article
Matrix Metalloproteinase Inhibitors Suppress Transforming Growth Factor-β-Induced Subcapsular Cataract Formation
Abstract
The pleotropic morphogen transforming growth factor-beta (TGFbeta) plays an important role in the development of fibrotic pathologies, including anterior subcapsular cataracts (ASCs). ASC formation involves increased proliferation and transition of lens epithelial cells into myofibroblasts, through epithelial-mesenchymal transformation that results in opaque plaques beneath the lens capsule. In this study, we used a previously established …
Authors
Dwivedi DJ; Pino G; Banh A; Nathu Z; Howchin D; Margetts P; Sivak JG; West-Mays JA
Journal
American Journal Of Pathology, Vol. 168, No. 1, pp. 69–79
Publisher
Elsevier
Publication Date
January 2006
DOI
10.2353/ajpath.2006.041089
ISSN
0002-9440
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlotting, WesternCadherinsCataractCulture Media, ConditionedDisease Models, AnimalEnzyme InhibitorsGene ExpressionImmunohistochemistryLasersLens, CrystallineMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMicrodissectionOrgan Culture TechniquesRatsReverse Transcriptase Polymerase Chain ReactionTransforming Growth Factor beta