Journal article
Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria
Abstract
The mechanism of proteinuria in many common kidney diseases involves glomerular hemodynamic effects and local expression of angiogenic, fibrogenic, and vasoactive factors. Transforming growth factor (TGF)-β has been associated with many diseases involving proteinuria and renal fibrosis. TGF-β has been shown to induce podocyte dedifferentiation in vitro, but its in vivo effects on the glomerular filtration barrier are not well described. In this …
Authors
Ghayur A; Liu L; Kolb M; Chawla A; Lambe S; Kapoor A; Margetts PJ
Journal
American Journal Of Pathology, Vol. 180, No. 3, pp. 940–951
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.ajpath.2011.11.023
ISSN
0002-9440
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAdenoviridaeAngiopoietin-1Angiopoietin-2AnimalsCell DedifferentiationCells, CulturedDown-RegulationFemaleGene Transfer TechniquesGenetic VectorsGlomerular Filtration BarrierKidney GlomerulusMembrane ProteinsPodocytesProteinuriaRatsRats, Sprague-DawleySnail Family Transcription FactorsSynaptophysinTranscription FactorsTransforming Growth Factor beta1