Treatment of intractable Menière's disease with intratympanic gentamicin: review of the University of Ottawa experience.

OBJECTIVE: Intractable Meniere's disease has traditionally been treated surgically, with either labyrinthectomy, vestibular nerve section, or endolymphatic sac procedures. Another option is the use of intratympanic gentamicin to effect a 'gentamicin labyrinthectomy.' Nedzelski and coworkers have previously reported an 83% complete elimination and 17% substantial reduction in vertigo using this method. METHOD: We retrospectively reviewed 21 …