Journal article
Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease
Abstract
The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 µM, was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose-dependent delay in the loss of climbing activity and activity pattern was …
Authors
Siddique YH; Khan W; Fatima A; Jyoti S; Khanam S; Naz F; Rahul R; Ali F; Singh BR; Naqvi AH
Journal
Disease Models & Mechanisms, Vol. 9, No. 1, pp. 63–68
Publisher
The Company of Biologists
Publication Date
January 1, 2016
DOI
10.1242/dmm.022145
ISSN
1754-8403
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AlginatesAnimalsAnimals, Genetically ModifiedBrainBromocriptineCrosses, GeneticDisease Models, AnimalDose-Response Relationship, DrugDrosophila melanogasterFemaleGlutathioneGlutathione TransferaseLipid PeroxidationMaleNanocompositesParkinson DiseasePermeabilitySolubilitySpectrophotometry, UltravioletSpectroscopy, Fourier Transform Infrared