Journal article
DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants
Abstract
The development of neural connectivity is essential for brain function, and disruption of this process is associated with autism spectrum disorders (ASDs). DIX domain containing 1 (DIXDC1) has previously been implicated in neurodevelopmental disorders, but its role in postnatal brain function remains unknown. Using a knockout mouse model, we determined that DIXDC1 is a regulator of excitatory neuron dendrite development and synapse function in …
Authors
Kwan V; Meka DP; White SH; Hung CL; Holzapfel NT; Walker S; Murtaza N; Unda BK; Schwanke B; Yuen RKC
Journal
Cell Reports, Vol. 17, No. 7, pp. 1892–1904
Publisher
Elsevier
Publication Date
11 2016
DOI
10.1016/j.celrep.2016.10.047
ISSN
2639-1856