Journal article
Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis
Abstract
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used classes of drugs, with the former frequently coprescribed to reduce gastroduodenal injury caused by the latter. However, suppression of gastric acid secretion by PPIs is unlikely to provide any protection against the damage caused by NSAIDs in the more distal small intestine.
METHODS: Rats were treated with …
Authors
Wallace JL; Syer S; Denou E; de Palma G; Vong L; McKnight W; Jury J; Bolla M; Bercik P; Collins SM
Journal
Gastroenterology, Vol. 141, No. 4, pp. 1314–1322.e5
Publisher
Elsevier
Publication Date
October 2011
DOI
10.1053/j.gastro.2011.06.075
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
2-PyridinylmethylsulfinylbenzimidazolesActinobacteriaAnimalsAnti-Inflammatory Agents, Non-SteroidalBifidobacteriumCelecoxibColonDenaturing Gradient Gel ElectrophoresisDisease Models, AnimalDrug InteractionsGastrointestinal HemorrhageHematocritJejunumLansoprazoleMaleNaproxenOmeprazolePeptic UlcerProbioticsProton Pump InhibitorsPyrazolesRatsRats, WistarReverse Transcriptase Polymerase Chain ReactionSulfonamidesTime Factors