Journal article
Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID
Abstract
The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAID enteropathy, using both a conventional NSAID (naproxen) and a gastrointestinal-safe naproxen derivative (ATB-346), as well as proton pump inhibitors (PPIs). Rats were treated orally with …
Authors
Blackler RW; De Palma G; Manko A; Da Silva GJ; Flannigan KL; Bercik P; Surette MG; Buret AG; Wallace JL
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 308, No. 12, pp. g994–g1003
Publisher
American Physiological Society
Publication Date
June 15, 2015
DOI
10.1152/ajpgi.00066.2015
ISSN
0193-1857