Journal article
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Abstract
BackgroundOver the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; …
Authors
The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium
Journal
Molecular Autism, Vol. 8, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s13229-017-0137-9
ISSN
2040-2392
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAutism Spectrum DisorderCarrier ProteinsCase-Control StudiesChromosomes, Human, Pair 10FemaleForkhead Transcription FactorsGene ExpressionGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHomeodomain ProteinsHumansMaleMembrane ProteinsPlasma Membrane Calcium-Transporting ATPasesRepressor ProteinsSchizophreniaTranscription Factors