Journal article
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
Abstract
Yuen et al. developed a cloud-based database with 5,205 whole genomes from families with autism spectrum disorder (ASD). They identified 18 new candidate ASD-risk genes and approximately 100 risk genes and copy-number loci, which account for 11% of the cases. They also found that individuals bearing mutations in ASD-risk genes had lower adaptive ability.
Authors
C Yuen RK; Merico D; Bookman M; L Howe J; Thiruvahindrapuram B; Patel RV; Whitney J; Deflaux N; Bingham J; Wang Z
Journal
Nature Neuroscience, Vol. 20, No. 4, pp. 602–611
Publisher
Springer Nature
Publication Date
April 2017
DOI
10.1038/nn.4524
ISSN
1097-6256