Journal article
Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study
Abstract
BACKGROUND: HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act synergistically to increase risk is unknown. We aimed to assess the contributions of these risk factors and the effect of established precursors of multiple sclerosis, such as brain lesions on MRI and oligoclonal bands in CSF at the time of incident demyelination, on …
Authors
Banwell B; Bar-Or A; Arnold DL; Sadovnick D; Narayanan S; McGowan M; O'Mahony J; Magalhaes S; Hanwell H; Vieth R
Journal
The Lancet Neurology, Vol. 10, No. 5, pp. 436–445
Publisher
Elsevier
Publication Date
May 2011
DOI
10.1016/s1474-4422(11)70045-x
ISSN
1474-4422
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute DiseaseAdolescentAge FactorsCanadaChildChild, PreschoolCohort StudiesDemyelinating DiseasesEnvironmental ExposureEpstein-Barr Virus InfectionsFemaleFollow-Up StudiesGenetic MarkersGenetic Predisposition to DiseaseHLA-DR AntigensHLA-DRB1 ChainsHumansMaleMultiple SclerosisProspective StudiesRisk Factors