Journal article
Combined effect of neonatal sympathectomy and adrenal demedullation on blood pressure and vascular changes in spontaneously hypertensive rats.
Abstract
Neonatal sympathectomy using a combined treatment with antiserum to nerve growth factor and guanethidine during the first 4 weeks after birth was carried out in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Bilateral adrenal demedullation was performed in 4-week-old sympathectomized SHR and WKY rats. The development of hypertension in SHR was prevented by sympathectomy, but the blood pressure (BP) was still …
Authors
Lee RM; Borkowski KR; Leenen FH; Tsoporis J; Coughlin M
Journal
Circulation Research, Vol. 69, No. 3, pp. 714–721
Publisher
Wolters Kluwer
Publication Date
September 1991
DOI
10.1161/01.res.69.3.714
ISSN
0009-7330