Journal article
Neuroimaging of mirtazapine enantiomers in humans
Abstract
IntroductionMirtazapine is a racemic antidepressant with a multireceptor profile. Previous studies have shown that the enantiomers of mirtazapine have different pharmacologic effects in the brain of laboratory animals.Materials and methodsIn the present study, we used positron emission tomography (PET) and autoradiography to study effects of (R)- and (S)-[11C]mirtazapine in the human brain. Detailed brain imaging by PET using three methods of …
Authors
Smith DF; Hansen SB; Jakobsen S; Bender D; Audrain H; Ashkanian M; Stork BS; Minuzzi L; Hall H; Rosenberg R
Journal
Psychopharmacology, Vol. 200, No. 2, pp. 273–279
Publisher
Springer Nature
Publication Date
10 2008
DOI
10.1007/s00213-008-1208-6
ISSN
0033-3158
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic alpha-AntagonistsAntidepressive Agents, TricyclicAutoradiographyBinding SitesBinding, CompetitiveBrainCarbon RadioisotopesClonidineDouble-Blind MethodHumansMaleMianserinMiddle AgedMirtazapinePositron-Emission TomographyRadioligand AssayRadiopharmaceuticalsStereoisomerismTissue DistributionYoung Adult