Journal article
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Abstract
Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were compared for HIST1H3B, IDH, ATRX and TP53 mutations, copy number alterations and clinical outcome. K27M-H3.3 occurred in 71 %, …
Authors
Khuong-Quang D-A; Buczkowicz P; Rakopoulos P; Liu X-Y; Fontebasso AM; Bouffet E; Bartels U; Albrecht S; Schwartzentruber J; Letourneau L
Journal
Acta Neuropathologica, Vol. 124, No. 3, pp. 439–447
Publisher
Springer Nature
Publication Date
September 2012
DOI
10.1007/s00401-012-0998-0
ISSN
0001-6322