Journal article
A Multicenter Trial of the Effectiveness of ζ-Globin Enzyme-Linked Immunosorbent Assay and Hemoglobin H Inclusion Body Screening for the Detection of α0-Thalassemia Trait
Abstract
Routine laboratories use a hemoglobin H (HbH) screen to detect alpha-thalassemia carriers of fatal hemoglobin Bart's hydrops fetalis. This test is laborious and has sensitivity concerns. A commercial zeta-globin enzyme-linked immunosorbent assay (ELISA) is effective in detecting Southeast Asian (SEA) alpha-thalassemia. We present results of a study of the effectiveness of carrier detection of ELISA and a shortened HbH screen compared with gap …
Authors
Lafferty JD; Barth DS; Sheridan BL; McFarlane AG; Halchuk LM; Raby A; Crowther MA
Journal
American Journal of Clinical Pathology, Vol. 129, No. 2, pp. 309–315
Publisher
Oxford University Press (OUP)
Publication Date
February 2008
DOI
10.1309/mnpf3xxxvax5nm9h
ISSN
0002-9173