Journal article
Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions
Abstract
Endoplasmic reticulum (ER) stress causes macrophage cell death within advanced atherosclerotic lesions, thereby contributing to necrotic core formation and increasing the risk of atherothrombotic disease. However, unlike in advanced lesions, the appearance of dead/apoptotic macrophages in early lesions is less prominent. Given that activation of the unfolded protein response (UPR) is detected in early lesion-resident macrophages and can enhance …
Authors
Dickhout JG; Lhoták Š; Hilditch BA; Basseri S; Colgan SM; Lynn EG; Carlisle RE; Zhou J; Sood SK; Ingram AJ
Journal
The FASEB Journal, Vol. 25, No. 2, pp. 576–589
Publisher
Wiley
Publication Date
February 2011
DOI
10.1096/fj.10-159319
ISSN
0892-6638