Journal article
The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils
Abstract
PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis). To date, the effects of PPAR agonists on chemokinesis have not been examined. This study investigates the effects of PPARα, δ, and γ agonists on eosinophil migration and chemokinesis. Eosinophils purified from blood of atopic donors were preincubated with rosiglitazone (PPARγ agonist), …
Authors
Smith SG; Imaoka H; Punia N; Irshad A; Janssen LL; Sehmi R; Gauvreau GM
Journal
PPAR Research, Vol. 2012, No. 1,
Publisher
Hindawi
Publication Date
2012
DOI
10.1155/2012/235231
ISSN
1687-4757