Journal article
Interleukin-5 Selectively Enhances the Chemotactic Response of Eosinophils Obtained From Normal but not Eosinophilic Subjects
Abstract
Abstract
We have attempted to determine whether interleukin-5 (IL-5), a cytokine that selectively affects eosinophil (as opposed to neutrophil) differentiation and activation, also modulates eosinophil migrational responses. Using a modified Boyden chemotaxis assay, IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gave a weak locomotory response for eosinophils from normal nonatopic subjects (optimal …
Authors
Sehmi R; Wardlaw AJ; Cromwell O; Kurihara K; Waltmann P; Kay AB
Journal
Blood, Vol. 79, No. 11, pp. 2952–2959
Publisher
American Society of Hematology
Publication Date
June 1, 1992
DOI
10.1182/blood.v79.11.2952.2952
ISSN
0006-4971