Journal article
Modulation of β1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjects
Abstract
BACKGROUND: Mobilization of hemopoietic progenitor cells from the bone marrow (BM) is a feature of inflammatory asthmatic responses. Understanding the mechanisms regulating progenitor cell mobilization and trafficking to the peripheral circulation might be important for the development of effective asthma therapies.
OBJECTIVE: We investigated the role of adhesion molecules in the mobilization of hemopoietic progenitor cells from the BM during …
Authors
Catalli AE; Thomson JV; Babirad IM; Duong M; Doyle TM; Howie KJ; Newbold P; Craggs RI; Foster M; Gauvreau GM
Journal
The Journal of Allergy and Clinical Immunology, Vol. 122, No. 4, pp. 803–810
Publisher
Elsevier
Publication Date
October 2008
DOI
10.1016/j.jaci.2008.07.021
ISSN
0091-6749
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAllergensAntigens, CD34AsthmaBone MarrowCD18 AntigensCell AdhesionCells, CulturedChemokinesFemaleFibronectinsGene Expression RegulationHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansInflammationIntegrin alpha4beta1Integrin alpha5beta1Integrin beta1Leukocyte Common AntigensMacrophage-1 AntigenMaleMiddle Aged