Journal article
Reassessing the Th2 cytokine basis of asthma
Abstract
T helper (Th) 2 cytokines, particularly interleukin 4 (IL-4), IL-5 and IL-13, might be important in the development of allergic asthma. Humanized monoclonal antibodies (hMAbs) against IL-5, and a recombinant soluble human IL-4 receptor have been developed as possible treatments for this disorder. However, these approaches have not yet proven to be successful in the treatment of persistent asthma, suggesting that neither IL-4 nor IL-5 is …
Authors
O'Byrne PM; Inman MD; Adelroth E
Journal
Trends in Pharmacological Sciences, Vol. 25, No. 5, pp. 244–248
Publisher
Elsevier
Publication Date
May 2004
DOI
10.1016/j.tips.2004.03.008
ISSN
0165-6147