Journal article
The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump
Abstract
BACKGROUND AND PURPOSE: Diphenyleneiodonium (DPI) is often used as an NADPH oxidase inhibitor, but is increasingly being found to have unrelated side effects. We investigated its effects on smooth muscle contractions and the related mechanisms.
EXPERIMENTAL APPROACH: We studied isometric contractions in smooth muscle strips from bovine trachea. Cholinesterase activity was measured using a spectrophotometric assay; internal Ca(2+) pump activity …
Authors
Tazzeo T; Worek F; Janssen L
Journal
British Journal of Pharmacology, Vol. 158, No. 3, pp. 790–796
Publisher
Wiley
Publication Date
October 2009
DOI
10.1111/j.1476-5381.2009.00394.x
ISSN
0007-1188