Journal article
Enhanced Myosin Phosphatase and Ca2+-Uptake Mediate Adrenergic Relaxation of Airway Smooth Muscle
Abstract
We examined the mechanisms underlying relaxations evoked by isoproterenol (Iso) in isolated porcine, bovine, or human tracheal and bronchial tissues (TSM and BSM, respectively). Iso had little effect against contractions evoked by high KCl, indicating that it does not directly suppress voltage-dependent Ca(2+)-influx nor directly inhibit myosin light chain kinase. Furthermore, Iso was equally potent against carbachol (CCh) contractions in the …
Authors
Janssen LJ; Tazzeo T; Zuo J
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 30, No. 4, pp. 548–554
Publisher
Oxford University Press (OUP)
Publication Date
April 2004
DOI
10.1165/rcmb.2003-0212oc
ISSN
1044-1549
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic beta-AgonistsAnimalsBronchiBronchodilator AgentsCalciumCalcium-Transporting ATPasesCarbacholCattleCholinergic AgentsElectrophysiologyHumansIn Vitro TechniquesIndolesIsoproterenolLungMuscle RelaxationMuscle, SmoothMyosin-Light-Chain PhosphatasePotassium ChlorideSarcoplasmic Reticulum Calcium-Transporting ATPasesSpecies SpecificityTrachea