Journal article
Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored with anti‐factor Xa levels
Abstract
BACKGROUND: Unfractionated heparin (UFH) is a widely used anticoagulant. Current American College of Chest Physicians guidelines for infants extrapolated from adults recommend 28 U kg(-1) h(1) of UFH to achieve an anti-factor Xa level of 0.35-0.7 IU mL(-1).
OBJECTIVE: To assess the profile of anti-FXa-based UFH dosing guidelines in infants.
Authors
SCHECHTER T; FINKELSTEIN Y; ALI M; KAHR WH; WILLIAMS S; CHAN AK; DeVEBER G; BRANDÃO LR
Journal
Journal of Thrombosis and Haemostasis, Vol. 10, No. 3, pp. 368–374
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1111/j.1538-7836.2012.04624.x
ISSN
1538-7933
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Age FactorsAnticoagulantsBlood CoagulationBlood Coagulation TestsChi-Square DistributionDrug Dosage CalculationsDrug MonitoringFactor Xa InhibitorsFemaleFibrinolytic AgentsHemorrhageHeparinHospitals, PediatricHumansInfantInfant, NewbornLogistic ModelsMaleOdds RatioOntarioPartial Thromboplastin TimePredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsThrombosisTreatment Outcome