Journal article
Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets
Abstract
Therapeutic monoclonal antibodies that target the conserved stalk domain of the influenza virus hemagglutinin and stalk-based universal influenza virus vaccine strategies are being developed as promising countermeasures for influenza virus infections. The pan-H1-reactive monoclonal antibody 6F12 has been extensively characterized and shows broad efficacy against divergent H1N1 strains in the mouse model. Here we demonstrate its efficacy against …
Authors
Krammer F; Hai R; Yondola M; Tan GS; Leyva-Grado VH; Ryder AB; Miller MS; Rose JK; Palese P; García-Sastre A
Journal
Journal of Virology, Vol. 88, No. 6, pp. 3432–3442
Publisher
American Society for Microbiology
Publication Date
March 15, 2014
DOI
10.1128/jvi.03004-13
ISSN
0022-538X