Carbon Capture and Storage (CCS) has become a crucial climate change mitigation strategy aimed at reducing net anthropogenic greenhouse gas emissions through the capture, transport, and permanent subsurface storage of CO2 from industrial sources or directly from the atmosphere. Its expanding role underscores the importance of identifying geologically suitable regions for future carbon storage. The Grand Banks region offshore eastern Canada remains underexplored for CCS despite its proximity to major CO2 sources, favourable geological formations, and existing offshore infrastructure that could be repurposed. However, the region’s tectonic activity, seismic history, and structural complexity necessitate detailed assessments to ensure secure CO2 injection and long-term storage.In this study, we evaluate CCS feasibility in the offshore Grand Banks region of Newfoundland, Canada using two-dimensional (2D) seismic reflection data, structural analysis, and numerical modeling. The objectives are to: 1) identify prospective CCS sites, 2) build a regional structural and fault framework, 3) investigate structural relationships between fault networks and salt structures, and 4) establish safe CO2 injection thresholds that minimize the risk of induced seismicity. Seismic profiles southwest of Newfoundland were interpreted using Petrel™ Schlumberger software to characterize the stratigraphic sequences, fault networks, and the geometry and distribution of salt structures. These interpretations were then integrated into the Petex™ MOVE suite to conduct fault and stress analyses on the regional structural fabric. The resulting interpretation and structural model, combined with logistical constraints like offshore distance and existing well infrastructure, facilitated the identification of candidate CCS sites and optimal injection locations. Geological parameters derived from seismic interpretation, including fault geometry and salt distribution, and reservoir porosity and permeability, were incorporated to assess storage integrity under multiple injection scenarios and define safe operational thresholds that minimize risks of induced seismicity and CO2 leakage. Numerical simulations were conducted to evaluate CO2 injection and migration behaviour within candidate reservoir-caprock pairs, highlighting leakage pathways and geomechanical responses of faults and caprocks to pressure changes.Our results reveal two dominant normal fault sets trending N-S and E-W, closely associated with various salt structures that play a crucial role in shaping the region’s subsurface architecture. The spatial correlation between the fault systems and salt distribution indicates their coupled evolution during Mesozoic rifting events and highlights a complex yet strategically favourable setting in which faults may act as either barriers or conduits to fluid flow, while certain salt bodies influence structural trapping efficiency.By providing foundational geoscientific assessments of the subsurface conditions, these findings advance understanding of CCS integration into the region’s energy infrastructure. This study introduces a multidisciplinary approach that provides a comprehensive framework for evaluating CCS potential in tectonically complex offshore settings and offers transferable insights for CCS deployment in similar geological environments worldwide, supporting climate change mitigation efforts and informed sustainable energy transition planning.