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In situ NMR and integrative proteomics reveal the...

Journal article

In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein

Abstract

Alpha-synuclein (αS) plays a central role in several neurodegenerative diseases. Although predominantly neuronal, αS is also present in peripheral fluids such as serum and cerebrospinal fluid (CSF), where it may contribute to disease propagation. However, its extracellular interactions remain poorly understood. By combining in situ NMR spectroscopy and bottom–up MS proteomics, we reveal that monomeric αS exhibits distinct interactomes in serum …

Authors

Huang J; Ahmed R; Akimoto M; Bozelli JC; Epand RM; Melacini G

Journal

Proceedings of the National Academy of Sciences, Vol. 123, No. 5,

Publisher

Proceedings of the National Academy of Sciences

Publication Date

February 3, 2026

DOI

10.1073/pnas.2521639123

ISSN

0027-8424

Associated Experts

Giuseppe Melacini

Professor, Faculty of Science

Labels

Medical Subject Headings (MeSH)

alpha-Synuclein Humans Proteomics Protein Binding Magnetic Resonance Spectroscopy

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