Some effects of scopolamine or locomotor activity in rats

On 2 consecutive days, rats (N = 30) were injected subcutaneously with saline, 0.2 mg/kg methscopolamine, or 0.2 mg/kg scopolamine, and tested for their levels of locomotor activity. Scopolamine produced hyperactivity on both days, while methscopolamine induced no effect different from that of saline. These results were discussed in relation to the suggestion of Calhoun & Smith (1968) that scopolamine impairs passive avoidance due to its effect on activity.