Journal article
Perioperative Heparin Bridging in Patients With Mechanical Aortic Valves Undergoing Elective Surgery: The AMBER Study.
Abstract
BACKGROUND: The benefit-risk balance of perioperative low-molecular-weight heparin (LMWH) bridging in patients with bileaflet mechanical aortic valves undergoing elective procedures is uncertain. While intended to prevent thromboembolism during warfarin interruption, LMWH may increase bleeding risk without a proven efficacy benefit. OBJECTIVES: This study aimed to evaluate the rates of thromboembolism and bleeding associated with different …
Authors
Godoy A; Grewal TS; Bhagirath V; Tafur A; McNiven Fontani A; Casanegra AI; Ghorbanzadeh A; Houghton DE; Abdulrehman J; Galanaud J-P
Journal
JACC Adv, Vol. 5, No. 2,
Publication Date
January 23, 2026
DOI
10.1016/j.jacadv.2025.102578