The incidence of early recurrent venous...

The incidence of early recurrent venous thromboembolism: a systematic review and meta-analysis

Abstract

Essentials

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Off-therapy D-dimer tests after VTE raise concern about early recurrence.

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We performed a systematic review and meta-analysis of studies of VTE patients anticoagulated for ≥3 months.

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Early recurrence was rare (1.04%). Stopping anticoagulation briefly appears safe.

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Off-therapy assessment may help guide treatment duration.

Eischer L; Kyrle PA; Kaider A; Schmidt A; Wildner B; Boc A; Bradbury C; Undas A; Couturaud F; Di Minno MND

Research and Practice in Thrombosis and Haemostasis, Vol. 10, No. 1,

Elsevier

January 1, 2026

10.1016/j.rpth.2025.103317

2475-0379

Sameer Parpia