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A modified X10-23 DNAzyme that can better access...

Journal article

A modified X10-23 DNAzyme that can better access large, structured RNA targets

Abstract

Abstract The 10–23 DNA enzyme is one of the most efficient RNA-cleaving enzymes reported, possessing substrate recognition arms that can be designed to target virtually any AU diribonucleotide junction. However, 10–23 often shows reduced activity for large, structured RNA (lsRNA) substrates like messenger RNA. Increasing arm length or adding antisense DNA oligonucleotides (ASOs) can improve accessibility to lsRNA but may also …

Authors

Nurmi C; Barber HM; Kaur H; Brennan JD; Damha MJ; Li Y

Journal

Nucleic Acids Research, Vol. 54, No. 1,

Publisher

Oxford University Press (OUP)

Publication Date

January 5, 2026

DOI

10.1093/nar/gkaf1449

ISSN

0305-1048

Associated Experts

John D Brennan

Professor, Faculty of Science

Yingfu Li

Professor, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

DNA, Catalytic Humans SARS-CoV-2 RNA, Viral RNA RNA Cleavage Oligonucleotides, Antisense Substrate Specificity Oligonucleotides RNA, Messenger Nucleic Acid Conformation DNA, Single-Stranded

Fields of Research (FoR)

31 Biological sciences 34 Chemical sciences 41 Environmental sciences

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