Randomised controlled trials for the prevention of venous thromboembolism in critically ill patients: A systematic review of sample size methodologies.

Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, contributes significantly to morbidity and mortality in critically ill patients. This increased incidence is influenced by factors such as indwelling central venous catheters, continuous sedation, and vasoactive infusions, in addition to traditional VTE risk factors such as immobility. Optimal VTE prophylaxis remains uncertain owing to significant …