Data from Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture

Abstract

<div>Abstract<p>Prostate cancer is one of the most heritable human cancers. Genome-wide association studies have identified at least 185 prostate cancer germline risk alleles, most noncoding. We used integrative three-dimensional (3D) spatial genomics to identify the chromatin interaction targets of 45 prostate cancer risk alleles, 31 of which were associated with the transcriptional regulation of target genes in 565 localized prostate tumors. …

Authors

Yuan J; Houlahan KE; Ramanand SG; Lee S; Baek G; Yang Y; Chen Y; Strand DW; Zhang MQ; Boutros PC

Publication Date

December 11, 2025

DOI

10.1158/2159-8290.c.8197665

Associated Experts

Katie Houlahan

Assistant Professor, Faculty of Health Sciences

Visit profile

View published work (Non-McMaster Users)