Consumption of low-digestible sugars increase susceptibility to Salmonella Typhimurium infection

Low-digestible carbohydrates (LDCs), including dietary fibers and sugars that resist absorption, are generally considered beneficial for the gut microbiota. However, we show that ingestion of certain LDCs, particularly low digestible sugars (LDSs) such as arabinose, lactulose, and polyols commonly used as sugar substitutes (e.g., erythritol, maltitol, and sorbitol), can compromise colonization resistance against the common foodborne pathogen Sal…