This chapter covers the most common hepatobiliary interventions encountered in interventional radiology. Image-guided biopsy of the liver is undertaken to obtain a tissue sample for pathological diagnosis of a lesion initially identified on imaging.Percutaneous cholecystostomy decompresses the gallbladder under fluoroscopic guidance and/or ultrasound guidance. This reduces symptoms and inflammation from acute cholecystitis. It is most useful in high-risk patients as a bridging therapy to cholecystectomy.Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and sixth most common malignancy worldwide. The premise of transarterial chemoembolization (TACE) is to induce ischemia of the tumor bed and increase susceptibility or response to chemotherapeutic agents, such as sorafenib. TACE can be used to treat patients who do not meet criteria for resection and to serve as a bridge therapy until transplant.