Impact of statin dose on major cardiovascular events: A mixed treatment comparison meta-analysis involving more than 175,000 patients

Abstract

BACKGROUND: The benefit of statins in the reduction of cardiovascular events was demonstrated in several placebo-controlled trials. More intensive therapy seems to be associated with greater benefit. Our objective was to compare different statin doses in the reduction of cardiovascular events and deaths, combining direct and indirect evidence, through mixed treatment comparisons (MTC). METHODS: We conducted a systematic review in MEDLINE and …

Authors

Ribeiro RA; Ziegelmann PK; Duncan BB; Stella SF; da Costa Vieira JL; Restelatto LMF; Moriguchi EH; Polanczyk CA

Journal

International Journal of Cardiology, Vol. 166, No. 2, pp. 431–439

Publisher

Elsevier

Publication Date

6 2013

DOI

10.1016/j.ijcard.2011.10.128

ISSN

0167-5273

Associated Experts

Steffan Frosi Stella

Associate Professor, Faculty of Health Sciences

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