Mechanostimulation of neuroendocrine cells and their clinical relevance

Mechanosensitive channels uniquely convert mechanical stimuli like pressure or stretch into electrochemical signals. They largely function as ion channels that create changes in electrochemical gradients across membranes. Mammals express a variety of mechanosensitive channels including piezo and transient receptor potential family members that have demonstrated essential functions in excitable tissues. Although the role of mechanosensitive …