A size exclusion chromatography- and ultrafiltration-based two-step process for purifying phage for therapeutic applications

The rise in the number of antibiotic-resistant bacteria has created the need for alternative therapeutic approaches, including bacteriophage therapy. Bacteriophages are viruses that infect and lyse bacteria and therefore offer a highly targeted and adaptable solution to combat multidrug-resistant pathogens. However, the scalable purification of bacteriophages, while achieving high yield of product and efficient removal of impurities such as …