The conceptualization, measurement, and critical appraisal of computational models of anhedonia in depression

Anhedonia, a cardinal feature of depressive disorders, is classically defined as an inability to experience pleasure, but modern definitions also encompass deficits in anticipatory pleasure and motivation. Validated scales and behavioural tasks have evolved alongside these conceptual shifts, and when integrated with computational modelling, may help reveal mechanisms underlying anhedonia. Reinforcement learning (RL) is the dominant …