Risk factors for patient-important upper gastrointestinal bleeding: A protocol and statistical analysis plan for a secondary analysis of the REVISE (Re-Evaluating the Inhibition of Stress Erosions) trial

Background: While studies have reported risk factors for clinically-important upper gastrointestinal bleeding among critically ill patients, the risk factors for patient-important upper gastrointestinal bleeding, as defined by ICU survivors and family members, are unknown. Further, although trials show that stress ulcer prophylaxis with pantoprazole decreases the risk of upper gastrointestinal bleeding, some research suggests that mortality may …