Machine Learning Models for the Assessment of the Mayo Endoscopic Score in Ulcerative Colitis Trial Endpoints: A Systematic Review

BACKGROUND: The Mayo endoscopic score (MES) provides a criterion-based, but still subjective, human assessment of endoscopy and related endpoints in therapeutic clinical trials in ulcerative colitis (UC). A novel solution to address issues of reproducibility is the use of machine learning (ML) models to standardize MES evaluations. Broader applicability of this solution requires an understanding of the models and related performance …