Journal article
The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment
Abstract
Metabolic dysfunction–associated steatotic liver disease (MASLD) is now recognized as a multisystem disease closely linked to cardiovascular disease, which is the leading cause of death in this population. MASLD and cardiovascular disease share overlapping pathophysiological mechanisms including insulin resistance, chronic inflammation, oxidative stress, and endothelial dysfunction that not only drive the progression of each disease but may …
Authors
Khan MS; Javaid SS; Dinani A; Wegermann K; Pandey A; Bhatt AS; Muthiah M; Van Spall HGC; Zannad F; Butler J
Journal
Journal of the American College of Cardiology, Vol. 86, No. 20, pp. 1861–1884
Publication Date
November 18, 2025
DOI
10.1016/j.jacc.2025.08.100
ISSN
0735-1097