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The Basics of Metabolic Dysfunction–Associated...
Journal article

The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment

Abstract

Metabolic dysfunction–associated steatotic liver disease (MASLD) is now recognized as a multisystem disease closely linked to cardiovascular disease, which is the leading cause of death in this population. MASLD and cardiovascular disease share overlapping pathophysiological mechanisms including insulin resistance, chronic inflammation, oxidative stress, and endothelial dysfunction that not only drive the progression of each disease but may …

Authors

Khan MS; Javaid SS; Dinani A; Wegermann K; Pandey A; Bhatt AS; Muthiah M; Van Spall HGC; Zannad F; Butler J

Journal

Journal of the American College of Cardiology, Vol. 86, No. 20, pp. 1861–1884

Publication Date

November 18, 2025

DOI

10.1016/j.jacc.2025.08.100

ISSN

0735-1097