Sig27 stratifies prostate cancer recurrence by assessing the immunosuppressive properties of tumors.

Prostate cancer (PC) remains a leading cause of cancer-related mortality in men, with recurrence contributing significantly to poor outcomes. Its molecular heterogeneity complicates effective risk stratification. We evaluated Sig27, a novel 27-gene panel, across 13 bulk RNA-seq datasets (n = 3,133 tumors) and 6 single-cell RNA-seq (scRNA-seq) datasets (n = 53 patients). Sig27 expression was elevated in PC compared to normal tissue and further …