Sig27 stratifies prostate cancer recurrence via assessing tumor’s immunosuppressive properties

Abstract

Prostate cancer (PC) remains a leading cause of cancer-related mortality in men, with recurrence contributing significantly to poor outcomes. Its molecular heterogeneity complicates effective risk stratification. We evaluated Sig27, a novel 27-gene panel, across 13 bulk RNA-seq datasets (n=3,133 tumors) and 6 single-cell RNA-seq (scRNA-seq) datasets (n=53 patients). Sig27 expression was elevated in PC compared to normal tissue and further …