Antibiotic-Loaded Calcium Crosslinked Alginate Wound Dressings Fabricated via Pressurized Gas eXpanded Liquids Technology in Combination with Supercritical Adsorptive Precipitation for Treating Methicillin-Resistant Staphylococcus Infections

Antibiotic resistance is a major healthcare challenge globally, and the development of antimicrobial therapies and modes for their targeted delivery is not keeping pace. Many promising antimicrobial candidates are abandoned early in discovery because of their high hydrophobicity and low bioavailability, limiting their evaluation in preclinical models. Therefore, developing drug delivery technologies compatible with potent yet hydrophobic …